Extended data Fig. 5: Analysis of sources of variation.

a, Box plot (center line: median, box limits: upper and lower quartiles, whiskers: 1.5x interquartile range, points outside whiskers: outliers) showing percentage variance explained by each covariate for genes that are differentially expressed between AD and Control groups in any of the identified cell types. b, Proportion of AD-vs-Control differentially expressed genes (DEGs) that are also individual-associated genes and genes that are only DE between AD and Control. c, Proportion of AD-vs-Control DEGs that are also sex-associated genes and genes that are only DE between AD and Control. The number of DEGs are given in parenthesis.