Extended data Fig. 3: Comparison of differentially expressed genes (DEGs) within microglia, OPCs and oligodendrocytes with Mathys et al. 2019. | Nature Neuroscience

Extended data Fig. 3: Comparison of differentially expressed genes (DEGs) within microglia, OPCs and oligodendrocytes with Mathys et al. 2019.

From: A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

Extended data Fig. 3

a, d, g, Venn diagram showing overlap of DEGs detected in Mathys et al. (n = 24 AD-pathology vs n = 24 no-pathology individuals) and those identified in the present study (n = 6 AD vs n = 6 control individuals) in microglia (a), OPCs (d) and oligodendrocytes (g), and the table shows the number of and concordance of dysregulation in AD of genes within the overlap of DEGs in both studies. Hypergeometric test was used to test for significance of overlap. b, e, h, List of concordant and discordant overlapping DEGs in microglia (b), OPCs (e) and oligodendrocytes (h). c, f, i, Significant gene ontology (GO) terms for each gene set comparison in microglia (c), OPCs (f) and oligodendrocytes (i). Multiple testing correction was done using the Benjamini–Hochberg method. Enrichment analysis was performed using hypergeometric test.

Back to article page