Extended Data Fig. 2: Peripheral expression and function of C4 in hC4 transgenic mice. | Nature Neuroscience

Extended Data Fig. 2: Peripheral expression and function of C4 in hC4 transgenic mice.

From: Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice

Extended Data Fig. 2

a, C4A- and C4B-specific mRNA level was measured by ddPCR in the spleen (left) and liver (right) of hC4A/- and hC4B/- mice. eiF4H was used as the control housekeeping gene (n = 4 mice per group; * PSpleen = 0.0286, * PLiver = 0.0286; two-tailed Mann-Whitney test). b, C4 hemolytic activity was measured with equal amounts of hC4A or hC4B protein using sensitized sheep red blood cells. Data were normalized to hC4A samples (n = 8 hC4A and n = 15 hC4B combined from 3 independent experiments; **** P < 0.0001, Unpaired, two-tailed t test). Bar graphs show mean ± s.e.m.

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