Extended Data Fig. 2: Expression of selected EC excitatory neuron subpopulation markers and pathway enrichment analysis of differentially expressed genes in selectively vulnerable EC excitatory neuron subpopulations.
From: Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease
a, Expression heatmap of genes that are specifically expressed by four or fewer EC excitatory neuron subpopulations; “High” and “Low” relative expression reflect above- and below-average expression, respectively (see Methods). b-d, Enrichment analysis against Gene Ontology Cellular Component terms or Reactome Pathways (b,d) and functional association network analysis (c,e; see Methods) of genes with higher (b-c) or lower expression (d-e) in RORB+ vulnerable EC excitatory neurons, with selected terms highlighted by color. In panels c and e, genes with stronger associations are connected by thicker lines, and genes without known associations are not shown.
