Extended Data Fig. 1: Association between cerebral atherosclerosis and oligodendrocyte abundance.
From: Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain
This figure summarizes the association between CA and oligodendrocyte abundance estimated from single-cell nuclear RNA sequencing of human dorsolateral prefrontal cortex in an independent dataset. Higher cerebral atherosclerosis was associated with higher oligodendrocyte abundance in the dorsolateral prefrontal cortex after adjusting for sex, age, and 8 other measured pathologies using linear regression (p = 0.003, β = 0.077, N = 48). For each box plot, the box reflects the first and third quartile, the dark horizontal line reflects the median, the vertical lines extending from the boxes show the 1.5x the interquartile range, and points beyond the lines are outliers.
