Extended Data Fig. 8: ZIKV-driven AHR activation suppresses IFN-I dependent and IFN-I independent mechanisms that limit viral replication.
From: AHR is a Zika virus host factor and a candidate target for antiviral therapy
IDO1/TDO2 upregulation induced by ZIKV infection boosts the generation of Kyn, which activates AHR to inhibit IFN-I dependent and IFN-I independent mechanisms that limit ZIKV replication as follows: 1) AHR activation limits IFN-I. 2) AHR also limits NF-kB activation, suppressing PML expression. AHR signaling may also operate in a similar manner to promote DENV replication.
