Extended Data Fig. 10: Model of neuronal regulation of the immune system during fasting. | Nature Neuroscience

Extended Data Fig. 10: Model of neuronal regulation of the immune system during fasting.

From: Fasting-activated ventrolateral medulla neurons regulate T cell homing and suppress autoimmune disease in mice

Extended Data Fig. 10

Orexigenic CAVLM neurons are activated during fasting, whose activation stimulates the release of glucocorticoids via the CAVLM→CRHPVN neural circuit targeting the adrenal glands, thereby driving T-cell homing to the bone marrow in a CXCR4CXCL12 axis-dependent manner and suppressing autoimmune diseases.

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