Extended Data Fig. 8: c-Fos expression in the S1HL and CeA from SNI mice. | Nature Neuroscience

Extended Data Fig. 8: c-Fos expression in the S1HL and CeA from SNI mice.

From: Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen

Extended Data Fig. 8

a,b, Representative confocal images (a) and quantitative analysis (b, SNI 1D/Sham 1D: S1HL vs CeA; F1,10 = 1434, left, P < 0.001; right, P = 0.05150) showing c-Fos+ and EYFP+ neurons in the S1HL and CeA of sham 1D and SNI 1D mice. Scale bar, 100 µm. c,d, Representative confocal images (c) and quantitative analysis (d, SNI 4W/Sham 4W: S1HL vs CeA; F1,10 = 638.5, left, P = 0.2245; right, P < 0.001) showing c-Fos+ and EYFP+ neurons in the S1HL and CeA of sham 4W and SNI 4W mice. Scale bar, 100 µm. Significance was assessed by two-way repeated-measures ANOVA with post hoc comparison between groups (b,d). All data are presented as the mean ± SEM. ***P < 0.001, not significant (n.s.). Details of the statistical analyses are presented in Supplementary Table 1.

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