Extended Data Fig. 4: Effect of psilocybin on locomotion behavior and encoding.
From: Psilocybin-enhanced fear extinction linked to bidirectional modulation of cortical ensembles
a, Diagram of experimental protocol. N = 3 GRIN lens-implanted mice were placed in dark open-field arenas and recorded with infrared cameras and Miniscope. Fifteen minutes into the session, mice were injected with psilocybin. Data for 2–14 minutes pre-injection and 10–42 minutes postinjection were used. b, Immobility bouts per minute pre-injection and postinjection (p = 0.5515, paired t test; Supplementary Table 4 (row 23)). c, Median bout length (p = 0.0459, paired t test; Supplementary Table 5 (row 24)). d, Total time immobile (p = 0.1081, paired t test; Supplementary Table 4 (row 25)). e, Mean ± s.e.m. distance between immobility-on and immobility-off trajectories in PC space. f, Single-cell discriminability of immobility vs. motion (median d′) pre-injection and postinjection (p = 0.8208, paired t test; Supplementary Table 4 (row 26)). g, Population discriminability of immobility vs. motion (mean distance in PC space) pre-injection and postinjection (p = 0.2882, paired t test; Supplementary Table 4 (row 27)). *p ≤ 0.05.
