Extended Data Fig. 5: Blood-derived proteins in embryonic CSF following ChP 5HT2C activation.
From: Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development
(A) Fluorescence intensity readings for hemoglobin and (B) hemopexin levels in E16.5 CSF after maternal saline or WAY-161503 injection, in SomaScan buffer solution, and in SomaScan human plasma calibrator. (C) Fluorescence intensity of top 25 common blood-derived proteins in CSF reveals no increases in WAY-161503-treated CSF compared to controls (saline-treated). (D) Heatmap summarizing fluorescence intensity of blood-derived proteins detected in CSF across conditions. Data Presentation: All data presented as mean ± SEM. P values from one-way ANOVA with Tukey correction for (A) and (B), and from two-way ANOVA with Sidak correction for (C) and (D).
