Extended Data Fig. 1: Sequence alignment and transducerome profiling of 5-HT5AR.
From: Inactive and active state structures template selective tools for the human 5-HT5A receptor
a, Sequencing alignment matrix of the 12 GPCR members in the 5-HT receptor family. Similarities are shown on the lower-left side of the table and identities on the upper-right. b, Transducerome screening of 5-HT5AR using TRUPATH platform by the endogenous agonist 5-HT. Net BRET values of 5-HT5AR together with positive controls of either neurotensin receptor 1 (NTSR1, agonist NT1-13) or β2AR (agonist isoproterenol) are shown in each panel. Data represent mean ± SEM of N = 3 biological replicates.
