Extended Data Fig. 10: Go binding to GPR156. | Nature Structural & Molecular Biology

Extended Data Fig. 10: Go binding to GPR156.

From: Constitutive activation mechanism of a class C GPCR

Extended Data Fig. 10

a–c, Comparison of Go binding between GPR156 and other class C GPCRs: GABAB-Gi1 (PDB: 7EB2 ref. 5) (a), mGlu2-Gi1 (7MTS ref. 6) (b), mGlu4-Gi3 (7E9H ref. 7) (c). The red arrows indicate the structural differences in the receptors and the G proteins. d. Sequence alignment of the residues in the α5 helix in different human Gα proteins. Residues interacting with GPR156 are marked with a light green circle. Absolutely conserved and highly conserved (≥50%) residues are marked with orange and yellow colors, respectively.

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