Extended Data Fig. 5: Structural predictions of DMXL1/2-ROGDI-WDR7 and the relationship between Rav1-C domains in DMXL1 and Rav1, related to Fig. 4. | Nature Structural & Molecular Biology

Extended Data Fig. 5: Structural predictions of DMXL1/2-ROGDI-WDR7 and the relationship between Rav1-C domains in DMXL1 and Rav1, related to Fig. 4.

From: DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation

Extended Data Fig. 5

a, Overlay of AF3 model of yeast Rav1-Rav2 with Rav1-Rav2 from 9COP56. Residues 1–21, 60–77, 227–293, and 349–351 are not present in Rav2 from 9COP. b, Overlay of the major helical regions of the Rav1-C ___domain for Rav1 (residues 756-1190) and the corresponding region in DMXL1 (residues 1318-1878). Green arrow indicates the ___location of the Rav1-C ___domain within the larger helical ___domain of DMXL1. c, Dmxl2-Rogdi-Wdr7 prediction by AF3. Lys-Lys crosslinks for Dmxl2-Rogdi-Wdr7 complex identified by Zhu et al.59 are shown by red lines (see Supplementary Table 4).

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