Fig. 5

Construction and validation of an independent prognostic signature. (a) Risk score distribution (the high-risk group was shown by red color and low risk was shown by green color), survival status (dead were shown by red color and green indicates alive), and signature gene expression in the TCGA (N = 127) and METABRIC (N = 320) merged data cohort (N = 447) divided into training cohort (N = 298) and testing cohort (N = 149) red color shows upregulation and green shows downregulation. (b) The KM curves of the merged training cohort (N = 298) were divided into a low-risk group have green color (N = 149) and a high-risk group have red color (N = 149). (c) The ROC curve of merged training cohort, low (N = 149), high (N = 149) risk group. 1-year area under was shown by yellow color, 3 years by green color, 5 years by blue and 7 years by red color. (d) The KM curve of the merged testing cohort (N = 147) was divided into a low-risk group (N = 75) and a high-risk group (N = 74). (e) The ROC curve of the merged testing cohort is low (N = 75) and high (N = 74) risk group. (f) The heatmap for the connections between the risk groups and clinical characteristics and sixteen genes upregulation were shown by red color and downregulation were shown by green color (g) The Nomogram calibration curves to predict the 1-, 3-,  and 5-year survival. 1 year represented by blue color, 3 years by green color, and 5 years by red color.