Figure 5 | Scientific Reports

Figure 5

From: Disruption of SHH signaling cascade by SBE attenuates lung cancer progression and sensitizes DDP treatment

Figure 5

Downregulation of SMO magnifies inhibitory effects of SBE on NSCLC cell proliferation. (A) Proliferation assay indicating that GDC or BMS and various dose of SBE cooperatively repress NSCLC cell proliferation. (B) Proliferation assay showing that low dose of SBE sensitized anti-proliferative effects of SMO inhibitor (GDC and BMS) on A549 and H1299 cells. (C) Immunoblotting analysis demonstrating that SBE enhanced GDC or BMS-induced repression of GLI1, SMO, and PTCH on protein level.

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