Figure 5 | Scientific Reports

Figure 5

From: Callistemenonone A, a novel dearomatic dibenzofuran-type acylphloroglucinol with antimicrobial activity from Callistemon viminalis

Figure 5

Antibacterial action of callistemenonone A (1). (A) Time-kill assay of MRSA (JCSC 2172) using 1 and vancomycin as control; (B) 1-induced membrane depolarization of MRSA with different concentrations in the presence of DiSC3-5, DMSO was used as the untreated control with no effect on the depolarization, 8 × MIC concentration of 1 can not induce membrane depolarization of E. coli; (C) SYTOX green assay of MRSA with 1 (8 × MIC = 160 μg/mL) and melittin (10 μg/mL) as positive control; (D) SYTOX green assay after treating MRSA with different concentrations of 1 for 4 h and melittin as positive control. MIC values: callistemenonone A = 20 μg/mL, melittin = 1.25 μg/mL.

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