Figure 2 | Scientific Reports

Figure 2

From: Dosage compensation in the process of inactivation/reactivation during both germ cell development and early embryogenesis in mouse

Figure 2

Comparisons of RNA-Seq gene expression levels between the X chromosome and autosomes in germ cell development. (A) X: A ratios of median expressions from germ cells when genes with no or very low expression are taken into consideration. The X: A ratio is significant closer to 0.5 compared to1 (Student’s t-test, p < 0.001). (B) For all types of germ cells, the X: A median expression ratios increased to close to 1 as no-/low-expression genes were gradually removed and remained stable after genes with FPKM ≤ 1 were removed. There were no differences between each types of germ cells. (P > 0.05, by Student’s t-test). (C) X: AA ratios of median expressions from germ cells when excluding no-/low-expression genes. There were no differences between each types of germ cells. (P > 0.05, by Student’s t-test) and the X: A ratio is significant closer to 1 compared to 0.5 (student’s t-test, p < 0.001). (D) Histograms of X-linked and autosomal expression distributions for male and female PGCs (mPGCs and fPGCs), FGSCs and NGO (Oocytes) (P > 0.05, by Kolmogorov-Smirnov test). The percentiles in all boxplots are 0.05, 0.25, 0.5, 0.75 and 0.95.

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