Figure 6 | Scientific Reports

Figure 6

From: Synergistic blending of high-valued heterocycles inhibits growth of Plasmodium falciparum in culture and P. berghei infection in mouse model

Figure 6

Antimalarial effect of Pht analogs (6h and 6u) alone and in combination with Artemisinin (6u and ART) on parasitemia and survival in mice infected with P. berghei NK65. Mice were injected with 1 × 107 P. berghei infected RBCs. After 48 hours mice were treated with control (PBS: untreated), 6h and 6u (alone), and 6u in combination with artemisinin (all injected subcutaneously) for four consecutive days. The % of parasitemia was determined for the groups on days 5, 8 and 15 by randomly selecting 10 different optical fields on blood smears. (A) Administration of 6h and 6u (alone), and 6 u in combination with ART. Data are the mean ± SEM from six animals per treatment group. (B) Survival in the treatment groups (n = 6/group). (C) Photomicrograph of blood smears of untreated versus treatment groups at day 15 post infection (100x magnification). ART, Artemisinin; *P < 0.05.

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