Figure 2
From: Fas Ligand-mediated cytotoxicity of CD4+ T cells during chronic retrovirus infection
CD4+ T cell response during chronic FV infection. C57BL/6 mice were chronically infected with FV (6 weeks post infection). (A) Percentages and absolute numbers of CD4+ Tetr II+ T cells reactive with I-Ab MHC class II tetramers specific for the FV H19-Env epitope. (B) Percentages and absolute numbers of CD4+ T cells showing the activation profile CD43+ and CD62L−. (C) Numbers per million cells of effector CD4+ T cells expressing proliferation marker Ki67. (D) Numbers per million cells of effector CD4+ T cells expressing the differentiation marker KLRG1. Each dot represents an individual mouse. Mean values are indicated by a line. Statistically significant differences between the groups were determined by the unpaired t test: *p < 0.05; **p < 0.005; ***p < 0.0001, ns, not significant. Data were pooled from two independent experiments.
