Figure 9
Mechanistic model for ATF3-mediated negative regulation of antiviral and autophagy pathways in the absence of type I IFN. Shown above are the antiviral and autophagy pathways that are triggered following the virus infection of a mammalian cell. Our study shows that ATF3 induced during JEV infection can bind to the promoter region of Stat1, Irf9, Isg15 to suppress the antiviral signaling. We also show ATF3 binding to Atg5 promoter, thereby suppressing the cellular antiviral pathway. The ATF3, thus, negatively regulates the cellular antiviral signaling and autophagy pathway in the absence of type I IFN.
