Figure 6
From: Atp6ap2 ablation in adult mice impairs viability through multiple organ deficiencies
Adult Atp6ap2 ablation results in colon disorganization and microadenomas. (A) Experimental design allowing seven days post-tamoxifen regimen to provide progression of colon defects. (B) Histological examination by haematoxylin and eosin (H&E) stain of Atp6ap2 cKO colons 11 days after beginning tamoxifen regimen. (C) H&E and Periodic acid Schiff (PAS) staining of colons of vehicle-control (VEH, panels i and ii), tamoxifen-treated (TAM, panels iii and iv), and Atp6ap2 vilTAM (panels v and vi). IP, intraperitoneal injection. Red arrow indicates early microadenoma and scale bars represent 400 µm.
