Figure 3 | Scientific Reports

Figure 3

From: M2-like macrophages in the fibrotic liver protect mice against lethal insults through conferring apoptosis resistance to hepatocytes

Figure 3

Macrophages exert dichotomous roles in cases of homeostasis and hepatic fibrosis. Macrophages in the control and fibrotic mice were depleted with liposome-clodronate (Clo) for 48 hours, and the resultant mice were then given a lethal dose of CCl4 by intraperitoneal injection. Sera and liver tissues were harvested 24 hours after toxin challenge. (a) Hepatic injury was assessed by serum ALT levels. (b and c) The mRNA and protein expressions of injury markers were detected by qRT-PCR and Luminex Assay, respectively. (d) Histological severity of liver injury was assessed and scored blindly by experienced pathologists. (e) Apoptotic cells were identified using TUNEL staining. Data were expressed as mean ± SEM.

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