Table 1 Inhibition values (Mean ± SEM) of neuraminidase-1 inhibitors from the plasma profile of Huang-Lian-Jie-Du-Tang (n = 3).

From: Inhibition activity of a traditional Chinese herbal formula Huang-Lian-Jie-Du-Tang and its major components found in its plasma profile on neuraminidase-1

Compounds

IC50 (μg/ml)

IC10 (μg/ml)

Baicalein

159.5 ± 13.4

75.0 ± 29.1

Baicalin

735.2 ± 59.1

75.0 ± 29.1

Berberine

78.6 ± 5.5

3.1 ± 0.8

Coptisine

104.6 ± 18.8

14.0 ± 2.5

Epiberberine

33.6 ± 0.3

4.1 ± 0.2

Geniposide

34.0 ± 1.8

2.8 ± 0.2

Jatrorrhizine

22.7 ± 0.2

1.9 ± 0.1

Oroxylin A

57.3 ± 6.3

5.1 ± 1.4

Oroxylin A 7-O-β-D-glucuronide

286.1 ± 44.2

29.3 ± 7.8

Palmatine

17.8 ± 0.8

2.1 ± 0.1

Phellodendrine

205.1 ± 18.9

23.1 ± 2.7

Wogonin

246.1 ± 10.3

34.0 ± 5.1

Wogonoside

186.4 ± 5.6

19.6 ± 2.7

Peramivir^

478.8 ± 15.6

64.8 ± 8.4

  1. ^neuraminidase inhibitor, positive control.
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