Figure 4
From: The AP-1 transcription factor JunB is required for Th17 cell differentiation
Junb-deficient mice are resistant to EAE. (A) EAE disease course in Junb f/+ (control) (n = 25) and Junb-deficient (KO) (n = 22) mice. Mean clinical scores are presented as mean ± SEM. (B and C) Pathological analysis in the spinal cord sections of mice on day 12 after EAE induction (n = 6). Arrowheads indicate demyelinated areas (Luxol fast blue) in (B). Scale bars in (B), 500 µm. Infiltrated cells were detected by immunostaining for CD3ε (T cells), B220 (B cells), and CD11b (myeloid cells) in (C). Scale bars in (C), 100 µm. (D) IL-17A production in MOG35–55-restimulated CD4+ T cells from mice with EAE. Error bars in (B,C and D) represent SD.
