Figure 1
Treatment with TLR ligands impacts survival of irradiated mice. Male C57BL/6 mice were irradiated (9.2 Gy TBI) and 24 hours later, received a single i.p. injection of physiological water (no treatment, NT), 2.5 mg/kg CpG–ODN2395 (CpG), 0.2 mg/kg Flagellin (Fla), 0.25 mg/kg MPLA, or 0.25 mg/kg FSL–1 (n = 10 per group). (a) Survival over 30 days post TBI, (b) clinical score and (c) percent body weight change of each treatment group was compared to irradiated, non–treated mice (TBI, NT). Data are representative of 2 independent experiments and are depicted as mean ± s.e.m. *P < 0.05, **P < 0.01 or ***P < 0.001 between treated and TBI, NT mice, with colors correlating to treatment group. Arrows indicate time post TBI in which remaining mice in group began to recover.
