Figure 1 | Scientific Reports

Figure 1

From: Expression of periaxin (PRX) specifically in the human cerebrovascular system: PDZ ___domain-mediated strengthening of endothelial barrier function

Figure 1

Expression of PRX in the human brain and in non-human tissues. Immunohistochemical analysis of human brain was performed with antibodies raised against human PRX. In the cerebral cortex, capillary staining (but not neurons or astrocytes) was detected in both gray (A) and white (B) matter. High power images demonstrate capillary and small vessel endothelial-predominant expression in the cortex (C). Positive vascular signals are highlighted with left pointing arrows. PRX mRNA was localized to capillaries by in situ hybridization ((D) pink granular stain shows RNA hybridization; left pointing arrows). Immunohistochemical analysis of PRX in mouse cortex (E) kidney (F,G) lung (H) and tail (I) was conducted for PRX expression using the same antibodies. Kidney and tail tissues demonstrated peripheral nerve staining while lung showed capillary expression (left pointing arrows). Right pointing arrows in (E–G) show endothelial cells that fail to stain for PRX in brain and kidney. Negative staining was observed in rat, pig, and marmoset brain (not shown). Scale bar for (A,B) shows 600 microns and for all other photographs measures 150 microns.

Back to article page