Figure 1 | Scientific Reports

Figure 1

From: Transcriptional network analysis of human astrocytic endfoot genes reveals region-specific associations with dementia status and tau pathology

Figure 1

Elevated AQP4 gene expression is associated with parietal cortical Aβ. (A) Expression levels of AQP4 were quantified across 4 brain regions, TCX, HIP, PCX, and FWM, in subjects with (blue, n = 57) and without (red, n = 50) dementia. Hippocampus demonstrates a trend towards elevated AQP4 in subjects with dementia (logistic regression, t = −0.947, padj = 0.087). (B) Significant associations between AQP4 expression with Aβ1–42 levels (center, OLS regression, t = 3.29, padj = 0.028), were detected in PCX. (C) No significant association between AQP4 expression and markers of tau pathology were detected in PCX. The bars in figure (A) represent the mean ± the standard deviation (S.D.). The line in figure (B) center represents the least squares (ordinary) fit for all data points that show a significant statistical association.

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