Figure 3 | Scientific Reports

Figure 3

From: Transcriptional network analysis of human astrocytic endfoot genes reveals region-specific associations with dementia status and tau pathology

Figure 3

Identification of novel endfoot gene candidates by Weighted Gene Correlation Network Analysis (WGCNA). (A) Cluster in which each of the five established endfoot genes assembled for each region. The cluster containing the greatest number of established endfoot genes was defined as the “endfoot enriched” cluster (bottom). Hub genes for each cluster are also identified. (B) Gene expression overlap for the “endfoot enriched” cluster across gray matter regions. (C) Consensus endfoot candidate genes identified by thresholding for astrocyte specificity (≥50% total expression), co-clustering with DAC genes across multiple brain regions, and high Pearson’s correlation with DAC genes.

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