Figure 8
GalXM loses the ability to induce the removal of fungal cells in the lung of C. neoformans-infected IL-6−/− mice. Mice were pretreated with PBS or capsular GalXM (250 μg/mL intratracheally) 24 h prior to an intratracheal injection with 106 C. neoformans cells. After 30 days, the mice were euthanized, and the lungs were recovered. Viable fungal cells were quantified in petri dishes containing agar from the homogenized organ. The results are expressed in CFUs (dilutions: 1:10 for wild type; 1:1000 for IL-6−/−). The results represent one of four independent experiments (n = 5 mice/group). The asterisk indicates *P < 0.05 relative to the control. The hash symbol (#) indicates P < 0.001 compared to the wild-type mice.
