Figure 2 | Scientific Reports

Figure 2

From: Low plasma haptoglobin is a risk factor for life-threatening childhood severe malarial anemia and not an exclusive consequence of hemolysis

Figure 2

Analysis of plasma haptoglobin and plasma free-hemoglobin of discovery cohort study groups at PD0. (a) Box plot of Log [plasma haptoglobin (ng/ml)] at admission (PD0) in the different study groups of the discovery cohort at PD0. SMA < CC (p < 0.0001); SMA < CM (p < 0.001); SMA < UM (p < 0.0001). (b) Box plot of Log [plasma free-hemoglobin (ng/ml)] at admission (PD0) in the different study groups of the discovery cohort at PD0. (p > 0.05 for all comparisons). The box plots show the IQR (box); the median (box line); and the 10–90 percentile (whiskers). Non-parametric Kruskal-Wallis with Dunn’s multiple comparison correction. (UM) = Uncomplicated Malaria; (SMA) = Severe Malarial Anemia; (CM) = Cerebral Malaria; (CC) = healthy malaria-negative Community Controls; PD0 = at admission prior to drug treatment and/or blood transfusion. IQR = Interquartile Q3-Q1 Range. For discovery cohort clinical groups details see Table 1.

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