Figure 4

Inhibition of ASPP2 suppresses the autophagic pathway in mice with 70% PHX. Representative western blotting analysis of Beclin-1, LC3, Atg-7 and p62 in the livers of ASPP2+/+ and ASPP2+/− mice at 0 h, 12 h, 24 h, and 48 h after 70% PHX. Quantifications were normalized to β-actin (n = 5 for each time point). Error bars represent the mean ± standard deviation (SD). *P < 0.05; *P < 0.01. Abbreviations: h, hour; N.S., no significant difference.