Figure 5 | Scientific Reports

Figure 5

From: Novel benzofuran derivative DK-1014 attenuates lung inflammation via blocking of MAPK/AP-1 and AKT/mTOR signaling in vitro and in vivo

Figure 5

Inflammatory cells, cytokines, and IgE in sensitized mice exposed to ovalbumin and DK-1014. Inflammatory cells were collected using centrifugation and stained with Diff-Quik stain reagent. (a) Cell count was determined by counting the cells in at least five hemocytometer squares using a light microscope after excluding dead cells using Trypan blue. (b) Cytokines in BALF quantified using an ELISA kit. (c) Total IgE and OVA-specific IgE in serum quantified using an ELISA kit. NC = normal control mice treated with PBS only; OVA = ovalbumin sensitized/challenged mice; Mon = ovalbumin sensitized/challenged mice treated with montelukast (30 mg/kg); DK-1014 = ovalbumin sensitized/challenged mice treated with DK-1014 (30 mg/kg). ##p < 0.005 compared to the normal control; *p < 0.05 and **p < 0.005 compared to OVA mice.

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