Figure 4
From: Activation of the PERK-ATF4 pathway promotes chemo-resistance in colon cancer cells
5-Fluorouracil and PERK inhibitor synergize to inhibit colon cancer in vivo. (A) (Tumor Volume) and (B) Tumors formed by SW620 cells in NOD/SCID mice treated with solvent control, 20 mg/kg 5-FU, 20 mg/kg PERK inhibitor, or combination of 5-FU and PERK inhibitor for 3 weeks. (C) Tumor weights of (B). (D) Ki67 staining for sectioning of tumors collected from (B). (E) Western blot showing the expression level of ATF4 and cleaved PARP of tumors collected from (B). β-Actin was used as loading control. Data are represented as mean ± SEM or the mean alone.
