Figure 4
From: Suppression of glioblastoma by a drug cocktail reprogramming tumor cells into neuronal like cells
FTT cocktail suppressed tumor growth and prolonged survival in GBM PDX. (A) Schematic diagram showing the procedure of in vivo experiments. (B–E) Immunostaining of TUJ1 (B), BrdU (C), and cleaved Caspase-3 (D) on brain sections of mice with indicated treatment. Scale bar, 50 μm. The quantification results are shown in E. (F,G) Bioluminescence live image monitoring orthotopic tumor growth. Images of 3 representative mice per group are shown in F. Data were statistically analyzed with two-way ANOVA and Tukey’s multiple comparisons test in G. (H) Kaplan-Meier survival analysis of GBM-bearing mice with indicated treatment. Log-rank test was used to calculate statistical significances. n = 11, 10, and 9 mice for vehicle, Temo, and FTT group. Data are represented as mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001.
