Figure 1
From: Beta cell secretion of miR-375 to HDL is inversely associated with insulin secretion
Pancreatic islets export miR-375-3p to HDL. (a) Quantification of miR-375-3p in plasma and HDL from WT mice. Correlation of plasma miR-375-3p levels and HDL-miR-375-3p levels. n = 5; Linear regression analysis. (b) MA plot of miRNA changes between cf-nHDL and islet-nHDL. n = 1 human donor. (c) miR-375-3p levels on cf-nHDL and islet-nHDL from three islet preps from individual donors. Donor 1: n = 6, donor 2: n = 3, donor: 3, n = 4; mean ± 95% CI; Two-tailed t-test. (d) Circos depicting top 100 islet miRNAs from 1 human donor (blue) and exported miRNAs from the same islets. sRNA-seq; dots represent RPM in islets and blue bars depict log2 HDL-miRNA fold change in islet-nHDL compared to cf-nHDL.
