Figure 4
From: Molecular architecture of the Jumonji C family histone demethylase KDM5B
HDX-MS heatmap of KDM5B residues 1–739. Top line above the numbering show ___domain regions in blue. Second line shows the amino acid sequence. Third line shows the DSSP56 derived secondary structural elements from the structure of KDM5B residues 1–760 (PDBID 5A1F)19 with α-helices in black and β-strands in blue. The fourth and the fifth lines show HDX-MS 15 seconds exchange heat maps for KDM5B and ccKDM5B, respectively. bars in the heatmap are colored according to the extent of HDX normalized to the equilibrium-labeled control. The color gradient for normalized deuterium exchange is shown in the bottom of the figure. Very short segments arise from differences of peptide lengths.
