Table 2 Association Between risk genotypes of ADRA2A, DRD2 and SLC6A4 genes and ADHD with Symptom Domains.

From: Prenatal Tobacco Exposure Modulated the Association of Genetic variants with Diagnosed ADHD and its symptom ___domain in children: A Community Based Case–Control Study

Symptom ___domain(N)

Model 1

Model 2

Model 3

OR

(95% CI)

OR

(95% CI)

OR

(95% CI)

ADRA2A rs553668a

All ADHD(160)

1.76*

(1.12–2.77)

2.07*

(1.27–3.37)

2.00*

(1.23–3.23)

Inattention(141)d

1.91*

(1.19–3.07)

2.05*

(1.26–3.36)

2.19*

(1.32–3.63)

Hyperactivity/impulsivity(78)e

2.18*

(1.21–3.94)

2.28*

(1.24–4.18)

2.37*

(1.29–4.34)

ODD(39)f

1.53

(0.72–3.25)

1.79

(0.82–3.91)

2.07

(0.92–4.66)

Control(225)

1

 

1

 

1

 

DRD2 rs1124491b

All ADHD(163)

2.22†

(1.11–4.46)

2.11†

(1.01–4.06)

2.38†

(1.33–5.83)

Inattention(143)d

2.11†

(1.01–4.06)

2.42†

(1.15–5.11)

2.11†

(1.03–4.39)

Hyperactivity/impulsivity(78)e

1.73

(0.76–3.94)

1.83

(0.79–4.26)

1.81

(0.78–4.19)

ODD(36)f

1.58

(0.52–4.77)

1.78

(0.57–5.59)

1.63

(0.53–5.00)

Control(222)

1

 

1

 

1

 

SLC6A4 rs6354c

All ADHD(167)

1.73†

(1.07–2.78)

1.51

(0.91–2.51)

1.55

(0.93–2.59)

Inattention(153) d

1.58

(0.97–2.56)

1.40

(0.84–2.42)

1.42

(0.83–2.43)

Hyperactivity/impulsivity(85)e

1.62

(0.91–2.88)

1.56

(0.85–2.84)

1.48

(0.80–2.73)

ODD(39)f

2.18†

(1.04–4.56)

2.38†

(1.09–5.19)

2.46†

(1.10–5.50)

Control(222)

1

 

1

 

1

 
  1. aThe ORs and 95% CIs were estimated the GG/AG vs AA genotype of ADRA2A rs553668; bThe ORs and 95% CIs were estimated the GG/AG vs AA genotype of DRD2 rs1124491: cThe ORs and 95% CIs were estimated the GT/GG vs TT genotype of SLC6A4 rs6354.d: all the patients with SNAP-IV inattention subscale score ≥ 1.6.e: all the patients with SNAP-IV hyperactivity subscale score ≥ 1.6.f: all the ADHD patients with SNAP-IV ODD subscale score ≥ 1.6.
  2. The ORs and 95% CIs were estimated by logistic regression model. Model 1:adjusted for participants age and gender; Model 2: variables in model 1plus pregnancy age of mother, family history of nervous system diseases, low birth weight, preterm birth; Model 3, variables in model 2 plus the blood lead concentration and postnatal tobacco smoke exposure.
  3. *p < 0 0.01, †p < 0.05.