Table 4 Replication of suggestive index SNPs reported in recent GWAS of BPH.
SNP | CHR:BP (hg19) | Gene | PMID | P-value | OR | EAab | OAac | eMERGE P-value | OR (95% CI) | eMERGE Effect Allele |
|---|---|---|---|---|---|---|---|---|---|---|
rs6537704 | 1:112052105 | ADORA3 | 28656603 | 1.1 × 10−5 | 1.34 | G | A | 0.17 | 1.08 (0.97–1.19) | T |
rs10915971 | 1:226508645 | PARP1 | 28656603 | 3.9 × 10−5 | 1.21 | A | G | 0.33 | 0.96 (0.88–1.04) | T |
rs10202096 | 2:28596317 | FOSL2 | 28656603 | 1.1 × 10−5 | 0.81 | A | G | 0.2 | 1.05 (0.97–1.13) | A |
rs2556378 | 2:60762502 | BCL11A | 30410027 | 3.4 × 10−12 | 1.12 | T | G | 0.020 | 1.13(1.03-1.22) | T |
rs12490648 | 3:27782163 | EOMES | 28656603 | 7.8 × 10−6 | 1.48 | G | A | 0.53 | 1.05 (0.89–1.22) | A |
rs7630221 | 3:37192199 | LRRFIP2 | 28656603 | 1.4 × 10−5 | 1.22 | A | G | 0.7 | 0.99 (0.92–1.06) | A |
rs3922844 | 3:38624253 | SCN5A | 28656603 | 1.8 × 10−5 | 1.23 | A | G | 0.37 | 0.97 (0.89–1.04) | T |
rs2853677 | 5:1287194 | TERT | 30410027 | 1.7 × 10−12 | 1.09 | G | A | 0.021 | 1.09 (1.02–1.17) | G |
rs381949 | 5:1322468 | CLPTM1L | 30410027 | 4.9 × 10−19 | 0.9 | A | G | 0.033 | 0.92 (0.85–1.00) | A |
rs2676245 | 5:13628062 | DNAH5 | 28656603 | 7.3 × 10−6 | 0.81 | A | G | 0.95 | 1.00 (0.93–1.08) | A |
rs10054105 | 5:110909333 | STARD4 | 30410027 | 3.5 × 10−12 | 0.91 | G | T | 0.80 | 0.99 (0.90–1.08) | G |
rs677394 | 5:134607559 | C5orf66, H2AFY | 30410027 | 2.9 × 10−11 | 0.88 | G | C | 0.50 | 0.96 (0.82–1.09) | G |
rs200476 | 6:27768348 | HIST1H2BL | 30410027 | 3.9 × 10−17 | 0.88 | T | A | 0.076 | 0.92 (0.82–1.01) | T |
rs17144046 | 10:8606014 | GATA3 | 28656603 | 8.9 × 10−7 | 1.41 | G | A | 0.068 | 1.08 (1.00–1.16) | A |
rs7906649 | 10:22310298 | EBLN1 | 30410027 | 2.1 × 10−7 | 1.07 | G | A | 0.74 | 1.01 (0.93-1.10) | G |
rs148678804 | 10:22427289 | DNAJC1 | 30410027 | 3.0 × 10−14 | 1.27 | A | G | 0.52 | 0.91 (0.63–1.19) | A |
rs7911634 | 10:56441151 | PCDH15 | 28656603 | 1.5 × 10−5 | 0.67 | A | C | 0.87 | 1.01 (0.87–1.16) | T |
rs4548546 | 10:122629579 | WDR11 | 30410027 | 2.0 × 10−16 | 1.11 | T | C | 0.099 | 1.07 (0.99–1.14) | T |
rs11199879 | 10:123045212 | FGFR2 | 30410027 | 5.7 × 10−23 | 1.14 | C | T | 0.0065 | 1.13 (1.04–1.21) | C |
rs72878024 | 11:199492 | ODF3 | 30410027 | 1.4 × 10−12 | 0.85 | A | G | 0.43 | 0.94 (0.79–1.09) | A |
rs428215 | 11:37126189 | RAG2 | 28656603 | 4.2 × 10−5 | 0.76 | G | A | 0.8 | 0.98 (0.87–1.10) | T |
rs10894022 | 11:129191124 | BARX2 | 28656603 | 2.6 × 10−5 | 0.79 | A | G | 0.48 | 0.97 (0.87–1.06) | T |
rs11613206 | 12:40609581 | LRRK2 | 28656603 | 4.9 × 10−5 | 1.15 | A | G | 0.81 | 0.98 (0.81–1.15) | A |
rs6538357 | 12:93150937 | PLEKHG7 | 28656603 | 4.9 × 10−5 | 0.84 | C | A | 0.61 | 0.98 (0.91–1.05) | A |
rs2555019 | 12:114668618 | TBX5 | 30410027 | 2.4 × 10−11 | 0.93 | T | C | 0.66 | 0.98 (0.91–1.06) | T |
rs8853 | 12:115108907 | TBX3 | 30410027 | 1.4 × 10−9 | 1.07 | C | T | 0.47 | 1.03 (0.95–1.10) | C |
rs1638703 | 13:51088356 | DLEU1 | 30410027 | 1.1 × 10−13 | 1.1 | C | G | 0.19 | 1.06 (0.98–1.14) | C |
rs6561599 | 13:51478918 | RNASEH2B | 30410027 | 1.8 × 10−7 | 0.94 | C | G | 0.26 | 0.96 (0.89–1.03) | C |
rs9302078 | 13:96171939 | CLDN10 | 28656603 | 3.0 × 10−5 | 0.83 | A | G | 0.67 | 1.02 (0.94–1.09) | A |
rs7152796 | 14:89924520 | FOXN3 | 28656603 | 4.0 × 10−5 | 1.46 | A | G | 0.94 | 0.99 (0.84–1.15) | T |
rs943587 | 14:97636701 | VRK1 | 28656603 | 0.80 | 1.11 | G | A | 0.96 | 1.00 (0.91–1.10) | A |
rs11651052 | 17:36102381 | HNF1B | 30410027 | 3.2 × 10−10 | 0.93 | A | G | 0.77 | 0.99 (0.92–1.06) | A |
rs9958656 | 18:19904144 | GATA6 | 30410027 | 4.3 × 10−19 | 1.11 | T | C | 0.031 | 1.08 (1.01–1.16) | T |
rs17670370 | 18:20034017 | CTAGE1 | 30410027 | 1.6 × 10−7 | 1.07 | G | T | 0.31 | 0.96 (0.87–1.04) | G |
rs11084596 | 19:32104979 | THEG5 | 30410027 | 2.1 × 10−24 | 0.88 | C | T | 0.33 | 1.04 (0.96–1.12) | C |
rs6061244 | 20:61041653 | GATA5 | 30410027 | 5.7 × 10−8 | 0.94 | C | G | 0.27 | 0.96 (0.88–1.03) | C |
rs200383755 | 20:61050522 | GATA5 | 30410027 | 3.2 × 10−9 | 0.67 | C | G | NA | NA | NA |
