Figure 4
From: Altered functional connectivity associated with time discounting in chronic pain
Functional connectivity associated with time discounting in chronic neck pain patients. (a) Significant positive networks associated with time discounting (TD) factor in whole brain analysis (pFDR < 0.05 and cluster criterion ≥2 links). Color and size of spheres represent community membership and the number of links (degrees), respectively. Color and width of links represent correlation value and intensity. (b) Association of the TD factor to brain functions of the identified network of right DLPFC to temporal lobe (TL). TD factor significantly associated with zr value and degree of the DLPFC-TL in the 5% link density. (c) Graph metrics of the DLPFC-TL network. Patients showed significantly higher degree and lower correlation. (d) Mediation analysis of the pathway from pain intensity to the log-transformed TD factor. Standardized regression coefficient ‘β’ was shown with 95% confidence interval. Indirect effect was computed in bootstrap method permuted 10000 times. (e) Association between pain intensity and degree of the whole DMN in the 5% link density. zr = Fisher’s z-transformed regression coefficient. All statistical analyses were controlled with age and gender.
