Figure 7
From: Functional characterisation of a novel class of in-frame insertion variants of KRAS and HRAS
GAP catalysed GTPase activity of VMOS related RAS variants. (A) Sequence alignment as in Fig. 2A of a KRAS variant found in a Noonan patient (case 7; this study), a HRAS variant found in two patients with Costello (lit 1;23,24) and of 6 variants of either KRAS or NRAS found in 8 different tumour samples (lit 2–7;25,26,27,28,29,30). The number of independent observations of the variant and the context is indicated on the right of the alignment. Colour coding as in Fig. 2A. (B) p(GTP) was determined at time zero and after 70 minutes of incubation in the presence of various concentration of RasGAP as in Fig. 5.
