Figure 5
Examples of putative recombining molecules in MGME1 knockout cells. Image interpretation and detail of the boxed area given in panels on the right. (A) 72 h ddC treatment of MGME1 KO cells resulted in marked increase in complexes including two or more mtDNA molecules (see Table 1 for quantifications). (B) Dimeric (2n) linear molecule attaching to a monomeric (1n) circle with a cruciform junction. The picture is a montage of two separate TEM images because of the size of the molecule. (C) Two 16.6 kb linear molecules attached to each other with a cruciform junction. The adjacent arms of the molecule are equally long, indicating that the junction is at a homologous locus.
