Figure 2 | Scientific Reports

Figure 2

From: Compensated pathogenic variants in coagulation factors VIII and IX present complex mapping between molecular impact and hemophilia severity

Figure 2

Differences between CPDs and noCPDs. For mutations of the two coagulation factors in our dataset, FVIII (top) and FIX (bottom), we computed the values of four properties: ∆∆G (change in protein stability upon mutation), relative solvent accessibility, BLOSUM62 matrix elements, and Shannon entropy. Using boxplots, we then separately represented the value distributions for the CPD (grey) and noCPD (striped) variants. There is a statistically significant tendency for noCPDs to adopt slightly more extreme values than CPDs, indicating that the latter are molecularly “milder” than the former.

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