Figure 3 | Scientific Reports

Figure 3

From: Space-like 56Fe irradiation manifests mild, early sex-specific behavioral and neuropathological changes in wildtype and Alzheimer’s-like transgenic mice

Figure 3

Brain inflammation was monitored by microPET imaging using a radiolabeled TSPO ligand, 18F-GE180. (a–c) To assess 56Fe irradiation effects on neuroinflammation, we analysed the tracer’s uptake and stable binding in whole brain (a), hippocampus (b) and thalamus (c). The thalamus was used as a reference brain region, due to lack of TSPO immunolabeling, as described in our previous study44. (d) The relative hippocampal uptake of 18F-GE180 was normalised by thalamus uptake. (e,f) No sex (e) or genotype (f) differences in hippocampal uptake of 18F-GE180 were found in pre-irradiation PET scans (baseline, n = 4 mice/group). Data analysed by 2-way ANOVA; mean ± SEM.

Back to article page