Figure 2
DAD suppresses LFPs in degenerating retina. (a) Raster plot and histogram of representative MEA recording in an rd1/rd1,Opn4−/− retina after treatment with 200 µM DAD. (b) Same as in A, with additional application of DNQX and D-AP5. (c) Same as in A, with additional application of CdCl2. (d) Quantification of light responses using the photoswitch index. (e) Graphical overview of pharmacological experiments. (f) Power spectrum of rhythmic firing due to oscillatory local field potentials before and after application of DAD. Heat plot represents spectral power at noted frequency in Hz. (g) Quantification of maximal frequency response before and after application of DAD (average intensities of complete time range). Maximum frequency with significant power is defined by the peak of the highest frequency reaching a threshold of 4 SD. Each data point refers to the power average of local field potentials in one retina. (n = 4 retinas). The average change in power is depicted in red with error bars (mean ± SEM).
