Figure 4
From: SLE Plasma Profiling Identifies Unique Signatures of Lupus Nephritis and Discoid Lupus
Protein signature associated with discoid lupus (DL). (a) Area under the curve (AUC) of biomarkers compared between plasma samples drawn from patients with DL versus those without cutaneous symptoms. (b) AUC of biomarkers compared between plasma samples drawn from patients with DL versus those with acute cutaneous lupus (ACL). (c,d) Anti-β2 microglobulin (β2 M) antibodies as measured by antigen microarray and total IgA concentration measured by Rules-Based Medicine in plasma samples from healthy donors (HD), patients with systemic lupus erythematosus (SLE) without cutaneous symptoms, patients with SLE and ACL, and patients with SLE and DL. Box and whiskers represent quartiles of each group. (e,f) Correlation between skin component of Lupus Activity Index (LAI) and anti-β2 M immunoglobulin (Ig) A and total IgA. Line represents best fit via robust linear regression. CL = cutaneous lupus; IL = interleukin.
