Figure 1
From: Identification and Validation of a Novel Biologics Target in Triple Negative Breast Cancer
GABRP gene expression in breast cancer. (A) List of the top differentially overexpressed genes between triple-negative (n = 73) and receptor-positive (n = 221) breast cancers, sorted by fold-difference. This data set includes Affymetrix U133A gene expression data from 294 fine-needle aspiration (FNA) samples of stage I-III breast cancers obtained at MDACC. (B) We used seven independent Affymetrix datasets separately to validate the overexpression of the identified genes in TNBC. The probesets were ranked according to the mean expression difference between TNBC and non-TNBC samples separately in the seven datasets and additionally in a combined pool of all 40 data sets and GABRP ranked most consistently as one of the first three probesets in these lists. (C) GABRP gene expression in different molecular subtypes of breast cancer. Box plots of GABRP gene expression measured by Affymetrix microarray (probeset 205044_at) are shown for molecular subtypes of breast cancer defined by a single marker method according to Hugh et al. (Hugh et al., 2009) among 4467 pre-therapeutic invasive breast cancer samples from 40 datasets. (D) GABRP gene expression in the intrinsic breast cancer subtypes as defined in The Cancer Genome Atlas (TCGA) dataset.
