Figure 3 | Scientific Reports

Figure 3

From: Aspirin enhances cisplatin sensitivity of resistant non-small cell lung carcinoma stem-like cells by targeting mTOR-Akt axis to repress migration

Figure 3

Aspirin sensitizes spheroids towards the anti-migration effect of cisplatin. (A) Graphical representation of the relative quantification of percent cell migration of A549, H1299 and H460 derived spheroids treated with different doses of cisplatin, doxorubicin and etoposide as detected by transwell migration assay. (B) Percent viability of PBMC treated with a dose range of genotoxic drugs, cisplatin, doxorubicin and etoposide, was scored by using trypan blue dye exclusion assay. (C) Representative bright field images of percent cell migration of A549 spheroids treated with 2.5 mM aspirin, 10 µM cisplatin, individually or in combination (left panel) and graphical representation of same (right panel). Scale bar 100 µm. Values are mean ± SEM of three independent experiments in each case or representative of typical experiment *p < 0.05, **p < 0.01,***p < 0.001.

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