Figure 2

Intrahepatic cholangiocarcinoma (ICC) in a 54–year-old male. (see Supplementary Video S2). (a) Conventional ultrasound shows a hypoechoic lesion with a size of 4.5 cm × 3.6 cm near the hepatic hilar region (cursors); (b) Color Doppler sonography indicates a relatively abundant blood supply; (c) During the arterial phase (18 s), the lesion exhibits heterogeneous hyperenhancement; (d) During the portal venous phase (100 s), the lesion exhibits hypoenhancement of its interior with hyperenhancement in the peripheral region, resulting in the formation of a hyperenhanced rim; (e) During the late phase (321 s), the lesion exhibits hypoenhancement; (f) The parametric curves reveal perfusion of the region of interest in the interior (light green, Peak = 50.0, Sharpness = 0.105 1/s) and periphery (dark green, Peak = 56.8, Sharpness = 0.030 1/s) of the lesion from 10 s to 180 s.