Table 2 Species-wise comparison of the nucleotide and amino acid divergence in the different gene regions and proteins of KFDV based on whole genome sequences (n = 48).
Region | Within host divergence | Between host divergence | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Monkey (M) | Tick (T) | Human (H) | M vs T | M vs H | T vs H | |||||||
Gene | Protein | Gene | Protein | Gene | Protein | Gene | Protein | Gene | Protein | Gene | Protein | |
Genome | 2.04 | 0.68 | 1.90 | 0.54 | 2.77 | 0.79 | 2.06 | 0.63 | 2.23 | 0.78 | 2.39 | 0.79 |
C | 2.84 | 2.62 | 2.48 | 2.46 | 2.69 | 2.20 | 2.86 | 2.77 | 2.69 | 2.40 | 3.00 | 2.66 |
prM | 1.81 | 1.02 | 1.66 | 0.86 | 2.29 | 1.64 | 1.81 | 0.97 | 2.12 | 1.53 | 2.31 | 1.51 |
E | 2.50 | 0.38 | 2.36 | 0.30 | 2.58 | 0.52 | 2.54 | 0.34 | 2.60 | 0.51 | 2.48 | 0.53 |
NS1 | 1.84 | 0.88 | 1.77 | 0.69 | 2.24 | 0.86 | 1.87 | 0.78 | 2.16 | 0.99 | 2.29 | 0.95 |
NS2 | 2.26 | 1.02 | 2.02 | 0.69 | 2.55 | 1.46 | 2.25 | 0.87 | 2.40 | 1.31 | 2.54 | 1.20 |
NS3 | 1.73 | 0.43 | 1.75 | 0.46 | 2.02 | 0.55 | 1.83 | 0.46 | 1.93 | 0.53 | 2.19 | 0.61 |
NS4 | 2.09 | 0.59 | 1.75 | 0.22 | 2.34 | 0.70 | 2.01 | 0.43 | 2.30 | 0.63 | 2.34 | 0.51 |
NS5 | 1.93 | 0.55 | 1.79 | 0.43 | 2.11 | 0.52 | 1.93 | 0.52 | 2.11 | 0.54 | 2.22 | 0.59 |