Figure 3 | Scientific Reports

Figure 3

From: A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration

Figure 3

Work-flow for identification of pleiotropic genes. Genome-wide significant independent GWAS signals (P-value ≤ 5 × 10−8) were extracted for 82 complex traits and diseases from the corresponding publications. Additionally, variants in LD for each of the independent GWAS hits were included in the analysis. Linked variants with R2 > 0.5 demarcated the start- and stop-positions for a GWAS signal R2 Locus. Overlapping loci were merged to identify potential pleiotropic genomic regions. The genes overlapping with at least one R2 locus were identified.

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